FAS Abstracts 2004 Meeting Page

Environmental Chemistry & Chemical Sciences B & Poster (ENV): ENV-11

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Initial evaluation of organotin monomers and polymers as potential anticancer agents. R.D. DOUCETTE, D.W. LOUDA , and C.E. CARRAHER.  Dept. of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431. A large number of metal-containing compounds show significant activity against cancer cells, and incorporating a metal into a polymer offers several possible advantages.  Compounds of the type R₂SnCl₂ (R=methyl, ethyl, propyl or butyl) were tested for the ability to inhibit the growth of  CAOV3 cells (human ovarian carcinoma cells). Polymers of 2-chloro-p-phenylenediamine and the same organotin chlorides were synthesized and tested as well. For both the monomers and the polymers, the pattern of growth inhibition relative to the R groups was butyl > propyl > ethyl > methyl; as the number of carbon atoms increases in the R group, the growth inhibition  increases. This and other aspects of the structure-activity relationships of the polymers will be discussed.