FAS Abstracts 2004 Meeting Page

Medical Sciences (MED): MED-6

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Carbohydrate composition of corpora amylacea in prostatic hypertrophy and carcinoma. R.A. MIRZA (1), M.D. CHUIDIAN (1), B. JONES (2) and A.T. MARIASSY (2). (1) Barry University, Miami Shores, FL 33161, (2) Nova Southeastern University, Ft. Lauderdale, FL 33328. As males age, the prostatic secretions within the prostatic ducts become calcified, laminated concretions termed corpora amylacea. The pathogenesis of the hypertrophy and neoplasia results in recognizable morphological changes. We hypothesize that their carbohydrate composition varies as well. Tissues were obtained from transurethral prostatectomies from patients with BPH and CA and examined histochemically for the relative abundance of concretions and their composition of neutral (magenta), acidic ab (dark blue), and mixed (purple) positively staining carbohydrate with ab/pas at ph 1.0 and 2.5. Results showed variably stained concretions in BPH; these were rare in CA. We conclude that the results may reflect lack of spatially differentiated glands in CA.