FAS Abstracts 2004 Meeting Page

Medical Sciences (MED): MED-18

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Differential behavior of fiber types in fast and slow twitch muscles following denervation. S. Richardson and S. Sesodia. SGMS, Barry University, 11300 NE 2nd Avenue, Miami Shores, FL 33161. Denervation leads to significant skeletal muscle fiber atrophy. However, the question of whether muscle fibers respond to denervation similarly in different types of muscles is still unresolved. In FAS 2003 we presented data on two muscles (soleus [SOL] and tibialis anterior [TA]) examining this question. We reported that in the fast twitch muscle, TA, type 1 fibers appeared to hypertrophy in contrast to the atrophy seen in these fibers in the SOL. However, the type 1 fiber data was from a small sample size and could not be tested statistically. The type 2 fibers atrophied in both muscles. We have extended and augmented our investigation into the response of the type 1 fibers and also comment on the change in the proportion of fibers following denervation.